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Mouse Anti-HSP90 beta/Gold Conjugated antibody (bsm-33136M-Gold)
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說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-33136M-Gold
英文名稱1 Mouse Anti-HSP90 beta/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的熱休克蛋白90β/HSP90 β 單克隆抗體
別    名 HSP90 beta; D6S182; FLJ26984; Heat shock 90kD protein 1, beta; Heat shock protein 90kDa alpha (cytosolic) class B member 1; Heat shock protein beta; Heat shock protein HSP 90 beta; HSP 84; HSP84; HSP 90; HSP-90 BETA; HSP90B; HSPC2; HSPCB; HS90B_HUMAN; Heat shock protein HSP 90-beta; Heat shock 84 kDa.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 2A2
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HSP90 beta
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].

Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Subunit:
Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4.

Subcellular Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Post-translational modifications:
Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity (Probable).

Similarity:
Belongs to the heat shock protein 90 family.

Database links:

Entrez Gene: 3326 Human

Entrez Gene: 15516 Mouse

Entrez Gene: 301252 Rat

Omim: 140572 Human

SwissProt: P08238 Human

SwissProt: P11499 Mouse

SwissProt: P34058 Rat

Unigene: 509736 Human

Unigene: 2180 Mouse

Unigene: 98667 Rat 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSP是細(xì)胞受應(yīng)激原刺激后誘導(dǎo)產(chǎn)生的一組應(yīng)激蛋白,與腫瘤發(fā)生、增殖及分化有關(guān),HSP90β能夠抑制細(xì)胞凋亡與分化。
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