| 產(chǎn)品編號 | bs-20750R-APC |
| 英文名稱1 | Rabbit Anti-UCP-2/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的線粒體脫偶連蛋白2抗體 |
| 別 名 | Uncoupling Protein-2; UCP2; UCP 2; BMIQ4; Mitochondrial uncoupling protein 2; SLC25A8; UCPH; Uncoupling protein 2; Uncoupling protein 2 mitochondrial proton carrier; Solute carrier family 25 member 8; UCP2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UCP-2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes. Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Subunit: Acts as a dimer forming a proton channel (By similarity). Subcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle. Similarity: Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats. Database links: Entrez Gene: 7351 Human Omim: 601693 Human SwissProt: P55851 Human Unigene: 80658 Human Unigene: 13333 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. UCP-2又稱解耦聯(lián)蛋白 2 (UCP2 )是 1997年發(fā)現(xiàn)的一種新的解偶聯(lián)蛋白 ,它是線粒體內(nèi)膜載體家族的一員 。與其類似物UCP1相比 ,UCP2在棕色脂肪組織中含量較低 ,但在體內(nèi)分布廣泛。解耦聯(lián)蛋白(UCP)具有使線粒體呼吸鏈解耦聯(lián)作用,解耦聯(lián)所釋放的能量以熱能的形式散發(fā)。在對UCP與產(chǎn)熱關(guān)系的研究中,發(fā)現(xiàn)UCP2具有調(diào)節(jié)機體能量代謝的功能,并且可能是肥胖與2型糖尿病相關(guān)聯(lián)的一個重要基因。 |
