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Rabbit Anti-RGS6/BF350 Conjugated antibody (bs-19862R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-19862R-BF350
英文名稱1 Rabbit Anti-RGS6/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子6抗體
別    名 FLJ43552; G protein signaling 6 regulator; GAP; GTPase activating protein; MGC142132; Regulator of G protein signaling 6; Regulator of G protein signalling 6; Regulator of G-protein signaling 6; RGS 6; RGS6; RGS6_HUMAN; S914.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RGS6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer.

Subunit:
Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).

Subcellular Location:
Cytoplasm. Membrane.

Similarity:
Contains 1 DEP domain.
Contains 1 G protein gamma domain.
Contains 1 RGS domain.

Database links:

Entrez Gene: 9628 Human

Entrez Gene: 50779 Mouse

Entrez Gene: 54295 Rat

Omim: 603894 Human

SwissProt: P49758 Human

SwissProt: Q9Z2H2 Mouse

SwissProt: P49801 Rat

Unigene: 509872 Human

Unigene: 153013 Mouse

Unigene: 199537 Rat

Unigene: 207298 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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