| 產(chǎn)品編號(hào) | bs-1294R-Bio |
| 英文名稱1 | Rabbit Anti-ODC/Biotin Conjugated antibody |
| 中文名稱 | 生物素標(biāo)記的鳥氨酸脫羧酶抗體 |
| 別 名 | Ornithine decarboxylase 1; Ornithine decarboxylase; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 2; DCOR_HUMAN; Ornithine decarboxylase 1; Ornithine decarboxylase; Ornithine decarboxylase structural 1; RNODC. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 信號(hào)轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ODC |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa. Subunit: Homodimer. Post-translational modifications: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. Database links: Entrez Gene: 4953 Human Entrez Gene: 18263 Mouse Omim: 165640 Human SwissProt: P11926 Human SwissProt: P00860 Mouse Unigene: 7133 Cow Unigene: 467701 Human Unigene: 34102 Mouse Unigene: 874 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 鳥氨酸脫羧酶為多胺生物合成途徑中的第一個(gè)限速酶 (催化合成多胺的第一步反應(yīng) ,即催化L -鳥氨酸脫羧生成腐胺 ) ,具有超常轉(zhuǎn)變率和對(duì)于刺激的迅速反應(yīng)性。 多胺廣泛存在于生物體的各種細(xì)胞和組織中 ,是一種重要的代謝調(diào)控物質(zhì) ,它可直接與DNA相互作用 ,調(diào)節(jié)DNA構(gòu)象 ,并參與RNA及蛋白質(zhì)的合成 ,與細(xì)胞增殖、分化密切相關(guān)。經(jīng)研究表明 ,哺乳動(dòng)物細(xì)胞增殖體現(xiàn)出完全的多胺依賴性。ODC主要存在于胞漿中。 |
