CAOPORN成人免费公开,欧美FREESEX黑人又粗又大 ,欧美狠狠入鲁的视频777色,主仆调教SM束缚绳索捆绑

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
张雨欣人文艺术欣赏PPT,性少妇JEALOUSVUE片
Rabbit Anti-RIPK-1/Cy5 Conjugated antibody (bs-5805R-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@www.tjshangbang.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@www.tjshangbang.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5805R-Cy5
英文名稱1 Rabbit Anti-RIPK-1/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的絲氨酸蘇氨酸激酶1受體相互作用蛋白抗體
別    名 Cell death protein RIP; Receptor (TNFRSF) interacting serine threonine kinase 1; Receptor interacting protein; Receptor interacting serine threonine protein kinase 1; Receptor TNFRSF interacting serine threonine kinase 1; Receptor-interacting protein 1; Receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; Rip-1; RIPK 1; Ripk1; RIPK1_HUMAN; Serine threonine protein kinase RIP; Serine/threonine-protein kinase RIP.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIPK-1/RIP
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Function:
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

Subunit:
Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By similarity).

Subcellular Location:
Cytoplasm. Cell membrane (By similarity).

Post-translational modifications:
Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.
RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is necessary for the formation of the necroptosis-inducing complex.
Ubiquitinated by 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear-linked type ubiquitin. Polyubiquitination with 'Lys-63'-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of 'Lys-63'-linked chains and polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequently downregulates TNF-alpha-induced NFkappa-B signaling. Linear polyubiquitinated; the head-to-tail polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated with 'Lys-11'-linked chains.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. [SIMILARITY] Contains 1 death domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 8737 Human

Entrez Gene: 19766 Mouse

Entrez Gene: 306886 Rat

Omim: 603453 Human

SwissProt: Q13546 Human

SwissProt: Q60855 Mouse

Unigene: 519842 Human

Unigene: 374799 Mouse

Unigene: 7572 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.www.tjshangbang.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产丰满麻豆VⅠDE0SEX| 国产欧美一区二区三区免费看| 日韩欧美在线高清视频| 成全动漫视频在线观看免费高清| 日韩欧美国产中文字幕| 再深点灬舒服灬太大了添视频| 欧美国产综合视频在线观看| 老熟女hdxx老小配| 激情影院内射美女| 香蕉视频色版| 最新中文字幕av专区 | 日韩欧美一区二区三区免费看| 免费一本色道久久一区| 国产美女被遭强高潮免费网站| 国产又色又爽又黄刺激的视频| 欧美日韩一区二区三| 男插女高潮一区二区| 在线看片免费人成视频久网下载 | 韩国黄片一级片| 国产精品日产三级在线观看| 福利网站视频| 色哟哟哟在线精品观看视频| 国内精品一区二区三区| 久久悠| 91欧美在线视频| 久久国产乱子伦精品免费乳及| 中文字幕一区在线观看视频| 2366zz宅宅电影免费| 中文字幕热久久久久久久| 中文字幕AⅤ人妻一区二区| 日韩性网站| XXXX性内射BBBB视| 少妇荡乳情欲办公室456视频| 亚洲中国最大AV网站| 久久国产劲爆AV内射—百度| 欧美午夜精品一区二区蜜桃| 麻豆www久久国产精品| 日日麻批免费40分钟无码| 欧美人妻激情在线| 老熟妇高潮一区二区三区| 小丫头你的第一次是我的|