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Rabbit Anti-Sema3A/Gold Conjugated antibody (bs-1121R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1121R-Gold
英文名稱 Rabbit Anti-Sema3A/Gold Conjugated antibody
中文名稱 膠體金標記的臂板蛋白3A抗體
別    名 Semaphorin 3A; Semaphorin-3A; Semaphorin-3A precursor; Semaphorin3A; SemD; Sema 3A; SEM3A_MOUSE; Coll 1; Coll1; Hsema I; Hsema III; sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3A; Sema III; SEMA1; SEMA1-PEN; SEMA3A; SEMAD; SEMAIII; SEMAL; Semaphorin III; Semaphorin like growth cone guidance homolog of chick collapsin; Semaphorin III; Semaphorin-D; Sema D.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Sema3A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

Function:
Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty.

Subunit:
Interacts with PXND1.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed at relatively high levels in brain and muscle, moderate levels in lung, bursa, and heart and virtually absent in liver. Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.

Similarity:
Belongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain.

Database links:

Entrez Gene: 10371 Human

Entrez Gene: 20346 Mouse

Entrez Gene: 29751 Rat

Omim: 603961 Human

SwissProt: Q14563 Human

SwissProt: O08665 Mouse

SwissProt: Q5BL08 Mouse

SwissProt: Q63548 Rat

Unigene: 252451 Human

Unigene: 44410 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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