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Rabbit Anti-EDG1/BF350 Conjugated antibody (bs-7112R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-7112R-BF350
英文名稱1 Rabbit Anti-EDG1/BF350 Conjugated antibody
中文名稱 BF350標記的內(nèi)皮細胞分化鞘脂G蛋白偶聯(lián)受體1抗體
別    名 CD363; CHEDG1; D1S3362; ECGF1; EDG1; EDG 1; Endothelial differentiation G-protein coupled receptor 1; Endothelial differentiation sphingolipid G protein coupled receptor 1; G protein coupled sphingolipid receptor; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1; S1PR1_HUMAN; Sphingosine 1 phosphate receptor Edg 1; Sphingosine 1 phosphate receptor EDG1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; Sphingosine 1phosphate receptor type 1 S1P1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  細胞凋亡  細胞粘附分子  G蛋白偶聯(lián)受體  內(nèi)皮細胞  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EDG1/CD363
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.

Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

Post-translational modifications:
S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 281135 Cow

Entrez Gene: 100050049 Horse

Entrez Gene: 1901 Human

Entrez Gene: 13609 Mouse

Entrez Gene: 29733 Rat

Omim: 601974 Human

SwissProt: Q5E9P3 Cow

SwissProt: P21453 Human

SwissProt: O08530 Mouse

SwissProt: P48303 Rat

Unigene: 154210 Human

Unigene: 982 Mouse

Unigene: 109455 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

研究發(fā)現(xiàn),S1P1與VEGF肩并肩相互協(xié)作,從而促進血管生長。VEGF是很多不同抗癌藥物的作用靶標。血管新生在很多疾病是異常的。靶向S1P1和VEGF可能要比只使用VEGF抑制劑更加有效地治療疾病;S1P1是一種關(guān)鍵性的血管新生反應(yīng)性基因。研究人員證實當新的血管網(wǎng)絡(luò)形成時,由此產(chǎn)生的血液流動激活血管內(nèi)皮細胞表面上的S1P1,并把信號傳遞到這些細胞內(nèi)部從而讓新形成的血管網(wǎng)絡(luò)穩(wěn)定化。因此阻斷S1P1可能有助于切斷給癌性腫瘤提供資源的血液供應(yīng)。
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