| 產(chǎn)品編號(hào) | bs-0011R-BF488 |
| 英文名稱 | Rabbit Anti-Gastrin Releasing Peptide/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的促胃泌素釋放肽抗體 |
| 別 名 | Gastrin releasing peptides; BN; Bombesin; GRP 10; GRP; GRP10; Neuromedin C; NeuromedinC; Pre progastrin releasing peptide; preproGRP; proGRP; GRP_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 神經(jīng)生物學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 3kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear. Subcellular Location: Secreted. Tissue Specificity: Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus. Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family. Database links: Entrez Gene: 2922 Human Entrez Gene: 225642 Mouse Omim: 137260 Human SwissProt: P07492 Human SwissProt: Q8R1I2 Mouse Unigene: 153444 Human Unigene: 20298 Mouse Unigene: 10930 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GRP廣泛分布于神經(jīng)系統(tǒng)、胃腸道以及正常肺組織中，是神經(jīng)內(nèi)分泌激素。在多種腫瘤中以自分泌方式分泌。能調(diào)節(jié)表皮生長因子，具有多種生物活性。 |
