| 產(chǎn)品編號(hào) | bs-2377R-APC |
| 英文名稱 | Rabbit Anti-CNR2/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的鈣粘蛋白相關(guān)的神經(jīng)受體2抗體 |
| 別 名 | Cannabinoid receptor 2; Cannabinoid Receptor II; Cannabinoid receptor 2 macrophage; CB 2; CB-2; CB2; CNR2; CNRII; CNR-2; CNR 2; CX 5; CX5; CNR2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)胞膜受體 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CNR2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]. Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Subcellular Location: Cell membrane. Cell projection, dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons. Tissue Specificity: Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level). Post-translational modifications: Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 1269 Human Entrez Gene: 12802 Mouse Omim: 605051 Human SwissProt: P34972 Human SwissProt: P47936 Mouse Unigene: 73037 Human Unigene: 297251 Mouse Unigene: 48776 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 大麻素受體2(大麻素II型受體)CB2受體在正常皮膚主要分布于上皮細(xì)胞、巨噬細(xì)胞、肥大細(xì)胞、感覺神經(jīng)纖維、毛囊、汗腺等部位, 參與皮膚感覺傳導(dǎo)、疼痛機(jī)制、皮膚免疫、皮膚腫瘤、細(xì)胞分化等重要的生理病理過(guò)程. |
