| 產(chǎn)品編號(hào) | bs-0168R-BF488 |
| 英文名稱(chēng)1 | Rabbit Anti-GFRA4/BF488 Conjugated antibody |
| 中文名稱(chēng) | BF488標(biāo)記的GDNF家族受體α4抗體 GDNFRα4 |
| 別 名 | Persephin receptor; GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 通道蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GFRA4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Subcellular Location: Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor. Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor. Isoform GFRalpha4c: Secreted. Tissue Specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. Similarity: Belongs to the GDNFR family. Database links: Entrez Gene: 64096 Human SwissProt: Q9GZZ7 Human Unigene: 302025 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Persephin receptor 是一個(gè)新的神經(jīng)營(yíng)養(yǎng)因子，屬于GDNFR家族，調(diào)節(jié)GDNF誘導(dǎo)的自動(dòng)磷酸化和RET受體的活性。他在維持神經(jīng)系統(tǒng)正常生存中起重要作用。主要表達(dá)在正常和惡性甲狀腺髓細(xì)胞。分子量約為30kDa。 |
