| 產(chǎn)品編號(hào) | bs-3787R-BF488 |
| 英文名稱1 | Rabbit Anti-SCD1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的固醇酰輔酶A脫氫酶1抗體 |
| 別 名 | ACOD_HUMAN; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Delta-9-Desaturase; FADS5; Fatty acid desaturase; PRO0998; SCD 1; SCD; SCD1; Stearoyl-CoA Desaturase. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 合成與降解 脂蛋白 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCD1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme is constitutively expressed in adipose tissue and is induced in liver in response to a fat free, high carbohydrate diet. SCD1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders. Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Similarity: Belongs to the fatty acid desaturase family. Database links: Entrez Gene: 6319 Human Entrez Gene: 20249 Mouse Omim: 604031 Human SwissProt: O00767 Human SwissProt: P13516 Mouse Unigene: 558396 Human Unigene: 597496 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 固醇酰輔酶A脫氫酶1(SCD1)是催化細(xì)胞中飽和脂肪酸(SFA)轉(zhuǎn)化為單不飽和脂肪酸(MUFA)的限速酶，在調(diào)控脂肪酸代謝、維持能量平衡、調(diào)節(jié)胰島素敏感性及衰老等方面都發(fā)揮著重要作用，近來在肥胖、激素調(diào)節(jié)、對瘦素的作用等研究受到了重視。 |
