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Rabbit Anti-CETP/PE-Cy3 Conjugated antibody (bs-3694R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3694R-PE-Cy3
英文名稱1 Rabbit Anti-CETP/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的膽固醇酯轉移蛋白抗體
別    名 BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; Cholesteryl ester transfer protein precursor; HDLCQ10; Lipid transfer protein I.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  脂蛋白  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CETP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

Function:
Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

DISEASE:
Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).

Similarity:
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Database links:

Entrez Gene: 1071 Human

Omim: 118470 Human

SwissProt: P11597 Human

SwissProt: P22687 Rabbit

Unigene: 89538 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CETP系一疏水糖蛋白,膽固醇酯轉運蛋白--介導HDL中的膽固醇與VLDL中的甘油三酯等交換,促進HDL中的膽固醇凈轉運,可促進膽固醇酯在細胞與血漿脂蛋白間的轉運,參與膽固醇的逆轉運過程。
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