CAOPORN成人免费公开,欧美FREESEX黑人又粗又大 ,欧美狠狠入鲁的视频777色,主仆调教SM束缚绳索捆绑

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
久久综合九色综合欧美狠狠,好紧好大快点舒服使劲,给我免费播放片在线观看
Rabbit Anti-CBL2/Biotin Conjugated antibody (bs-2757R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@www.tjshangbang.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@www.tjshangbang.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2757R-Bio
英文名稱1 Rabbit Anti-CBL2/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的原癌蛋白CBL2抗體
別    名 C CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; CBL 2;E3 ubiquitin protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; RGD1561386; RING finger protein 55; RNF55v Signal transduction protein CBL; 4732447J05Rik; CBL_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CBL2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

Function:
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

Subunit:
Interacts (phosphorylated at Tyr-731) with PIK3R1. Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB (By similarity). Interacts with ALK, AXL, BLK, FGR and FGFR2. Interacts with CSF1R, EPHB1, FLT1, KDR, PDGFRA and PDGFRB; regulates receptor degradation through ubiquitination. Interacts with HCK and LYN. Interacts with TEK/TIE2 (tyrosine phosphorylated).

Subcellular Location:
Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Post-translational modifications:
Phosphorylated on tyrosine residues by ALK, EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues in response to FLT1 and KIT signaling. Phosphorylated on tyrosine residues by INSR and FGR. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Not phosphorylated at Tyr-731 by FGFR3. Phosphorylated on tyrosine residues by activated CSF1R, PDGFRA and PDGFRB. Phosphorylated on tyrosine residues by HCK.
Ubiquitinated, leading to its degradation via the proteasome.

DISEASE:
Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) [MIM:613563]: A syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects. Some have an increased risk for certain malignancies, particularly juvenile myelomonocytic leukemia. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
Contains 1 RING-type zinc finger.
Contains 1 UBA domain.

Database links:

Entrez Gene: 867 Human

Entrez Gene: 12402 Mouse

Entrez Gene: 500985 Rat

Omim: 165360 Human

SwissProt: P22681 Human

SwissProt: P22682 Mouse

Unigene: 504096 Human

Unigene: 266871 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

????CBL2(Casitas B-lineage lymphoma)是一類廣泛分布的細(xì)胞內(nèi)蛋白,屬于泛素連接酶E3, Cbl參與細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)的負(fù)向調(diào)控,這對(duì)于維持細(xì)胞的內(nèi)穩(wěn)態(tài)具有重要作用。Cbl突變后可成為癌蛋白;許多腫瘤細(xì)胞則表現(xiàn)為與增殖有關(guān)的分子(如受體型蛋白酪氨酸激酶,RTK)因發(fā)生突變或其它遺傳學(xué)改變不受Cbl負(fù)調(diào)控。加強(qiáng)或重建Cbl的負(fù)調(diào)控作用,或許能夠從受體活化的上游信號(hào)開始抑制腫瘤細(xì)胞增殖。為利用Cbl的泛素連接酶活性,并使其能夠特異性地降解某些信號(hào)轉(zhuǎn)導(dǎo)分子,從而對(duì)一些與腫瘤生長(zhǎng)有關(guān)的細(xì)胞增殖進(jìn)行負(fù)向調(diào)節(jié).
版權(quán)所有 2004-2026 www.www.tjshangbang.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲欧美国产国产一区二区| 国精产品一区二区三区有限| 久久中文字幕人妻丝袜| 调教玩弄奶头乳夹开乳震动器| 美女把尿口扒开让男人桶| 亚洲日韩在线观看免费视频| 国产精品内射久久久久欢欢| 呱呱吃瓜爆料黑料网曝门黑料| 中文字幕无码AV波多野吉衣| 公车挺进尤物少妇翘臀| 玩弄人妻少妇精品视频| 久久久久久九九99精品| 成人免费在线电影| 善良的女儿| 欧美亚洲国产精品专区| 最近免费中文字幕大全免费版视频| 美丽人妻在夫前被黑人| 董小宛 果冻传媒 麻豆| 亚洲欧美日韩愉拍自拍美利坚| 亚洲精品国产精品乱码不99| 亚洲熟妇AV一区二区三区浪潮| 久久青青草原精品国产 | 国产情侣一区二区三区| JAPAN丰满少妇VIDEOS| 久久青草国产手机看片福利盒子| 国产乱妇无码大片在线观看| 国产精品/综合区久久久久久| 久久亚洲精品无码| 不卡一区二区三区卡| 久久97精品久久久久久久不卡| 少妇被CAO高潮呻吟声| 天堂А√中文最新版地址在线| 玩弄CHINESE丰满人妻VIDEOS| 亚洲一级a大片一级| 丰满多毛的大隂户毛茸茸 | 久久国产亚洲AV无码麻豆| 少妇人妻在线无码天堂视频网| brazzerslisaannxxx| 一区二区三区性色福利在线视频| 欧美69精品久久久久久不卡| 91国内精品久久久久免费影院|