| 產(chǎn)品編號(hào) | bs-1167R-AP |
| 英文名稱 | Rabbit Anti-CCR3/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的細(xì)胞表面趨化因子受體3抗體 |
| 別 名 | CCR-3; CC chemokine receptor 3; Chemokine (C-C motif) receptor 3; MIP-1 alpha receptor like-2; B chemokine receptor; b-chemokine receptor; C C chemokine receptor type 3; C C CKR 3; C-C chemokine receptor type 3; CC chemokine receptor type 3; CC CKR 3; CC R3; CCCKR3; CCR 3; CCR3; CCR3_HUMAN; CD 193; CD193 antigen; chemokine (C-C motif) receptor 3; Chemokine (CC) receptor 1 like 2; Chemokine CC motif receptor 3; Chemokine receptor 3; CK R3; CKR 3; CMKB R3; CMKBR 3; CMKBR1L2; CMKBR3; Eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; Eotaxin receptor; Macrophage inflammatory protein 1 alpha receptor like 2; MGC102841; MIP1 Alpha RL2;Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2; MIP-1 alpha RL2; CD193. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Cow, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR-3 C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3(CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Subunit: Binds to HIV-1 Tat. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 1232 Human Entrez Gene: 12771 Mouse Omim: 601268 Human SwissProt: P51677 Human SwissProt: P51678 Mouse Unigene: 506190 Human Unigene: 57050 Mouse Unigene: 9890 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 趨化因子受體3(CCR3)主要在嗜酸粒細(xì)胞，Th2淋巴細(xì)胞，肥大細(xì)胞，支氣管上皮細(xì)胞上表達(dá)， CCR3介導(dǎo)嗜酸粒細(xì)胞內(nèi)有絲分裂原活化蛋白激酶（MAPK） 細(xì)胞外信號(hào)調(diào)節(jié)激酶-2（ERK2）、p38和JNK的活化。 |
