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Rabbit Anti-NAIF1/PE-Cy5.5 Conjugated antibody (bs-0452R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0452R-PE-Cy5.5
英文名稱 Rabbit Anti-NAIF1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的核凋亡誘導(dǎo)因子蛋白1
別    名 NAIF1 protein; nuclear apoptosis inducing factor 1; CB12-327; 2310007O20Rik; 4933440H19Rik; bA379C10.2; C9orf90; DKFZP762G199; NAIF1; RP11-379C10.2; NAIF1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NAIF1 N-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
NAIF protein 1 (nuclear apoptosis inducing factor 1; CB12-327; RP-379C10.2) belongs to the NAIF1 family. Apoptosis is a genetically determined cell suicidal pro gram that plays critical roles in many physiological and pathological processes. nuclear apoptosis-inducing factor 1 (NAIF1), overexpression of which induces apoptosis in cells. Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes or proteins. Northern blot analysis revealed wide expression of NAIF1 mRNA throughout human tissues. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed.

Function:
Induces apoptosis.

Subunit:
Interacts with HARBI1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the NAIF1 family.

Database links:

Entrez Gene: 510689 Cow

Entrez Gene: 203245 Human

Entrez Gene: 71254 Mouse

Omim: 610673 Human

SwissProt: A7MBH3 Cow

SwissProt: Q9BE21 Cynomolgus Monkey

SwissProt: Q69YI7 Human

SwissProt: Q6PFD7 Mouse

Unigene: 373606 Human

Unigene: 102341 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NAIF1 protein(CB12-327)是最新發(fā)現(xiàn)的大腸癌標(biāo)志物他抑制NFκB,NFAT,AP-1活性,并誘導(dǎo)細(xì)胞調(diào)亡。
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