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Rabbit Anti-Dopamine Receptor D1/Biotin Conjugated antibody (bs-1007R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1007R-Bio
英文名稱 Rabbit Anti-Dopamine Receptor D1/Biotin Conjugated antibody
中文名稱 生物素標記的多巴胺受體D1抗體
別    名 DRD1; dopamine D1 receptor; D(1A) dopamine receptor; D1A dopamine receptor; Dopamine D1Receptors; D1DR; DADR; Dopamine Receptor D1; DR D1; DR D1A; DRD 1; DRD1 receptor; DRD1; DRD1A; DRD1_HUMAN; D(1A) dopamine receptor; DRD 1A; DRD1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學  神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DRD1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Subunit:
Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Detected in caudate, nucleus accumbens and in the olfactory tubercle.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 1812 Human

Entrez Gene: 13488 Mouse

Entrez Gene: 24316 Rat

Omim: 126449 Human

SwissProt: P21728 Human

SwissProt: Q61616 Mouse

SwissProt: P18901 Rat

Unigene: 2624 Human

Unigene: 54161 Mouse

Unigene: 24039 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多巴胺受體D1在運動協(xié)調(diào)方面起重要作用,該受體的缺失對黑質(zhì)多巴胺能神經(jīng)元的影響程度雖沒臨床帕金森?。≒D)嚴重,但仍可加速多巴胺能神經(jīng)元發(fā)生退行性改變.該蛋白目前主要用于神經(jīng)退行性改變的研究。
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