| 產(chǎn)品編號(hào) | bs-1436R-BF488 |
| 英文名稱 | Rabbit Anti-PBP/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的磷脂酰乙醇胺結(jié)合蛋白1抗體 |
| 別 名 | phosphatidylethanolamine-binding protein; PEBP; PEBP 1; PBP; RKIP; Phosphatidylethanolamine-binding protein 1; PEBP-1; PEBP1; Prostatic-binding protein; Prostatic binding protein; Neuropolypeptide h3; HCNPpp; Raf kinase inhibitor protein; Hippocampal cholinergic neurostimulating peptide; HCNP. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RKIP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. [SUBCELLULAR LOCATION] Cytoplasm. Belongs to the phosphatidylethanolamine-binding protein family. Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Subcellular Location: Cytoplasm. Similarity: Belongs to the phosphatidylethanolamine-binding protein family. Database links: Entrez Gene: 5037 Human Entrez Gene: 23980 Mouse Omim: 604591 Human SwissProt: P30086 Human SwissProt: P70296 Mouse Unigene: 433863 Human Unigene: 195898 Mouse Unigene: 338476 Mouse Unigene: 473809 Mouse Unigene: 29745 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信號(hào)傳導(dǎo)（Signaling Intermediates） Raf激酶抑制蛋白(PKIP)屬于磷脂酰乙醇胺結(jié)合蛋白 （phosphatidylethanolamine-binding protein, PEBP）家族,廣泛存在于各種不同的生物中,PKIP還參與了對(duì)NF-kB信號(hào)通路和G蛋白偶聯(lián)受體信號(hào)通路的調(diào)控,參與NF-κB信號(hào)通路的調(diào)控,參與了對(duì)細(xì)胞內(nèi)多種信號(hào)轉(zhuǎn)導(dǎo)通路的調(diào)節(jié)作用。RKIP在膜的生物合成、精子發(fā)生、神經(jīng)發(fā)育和細(xì)胞凋亡等生理過(guò)程中發(fā)揮重要作用，并參與了老年癡呆癥及糖尿病等的病理過(guò)程。有學(xué)者認(rèn)為：RKIP有抑制腫瘤細(xì)胞轉(zhuǎn)移的作用。 |
