| 產品編號 | bs-0492R-Gold |
| 英文名稱 | Rabbit Anti-RGS2/Gold Conjugated antibody |
| 中文名稱 | 膠體金標記的G蛋白信號轉導調節(jié)因子2抗體 |
| 別 名 | Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulators of G protein signaling XRGSVI; RGS 2. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領域 | 免疫學 神經生物學 信號轉導 生長因子和激素 轉錄調節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, ) |
| 產品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RGS2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產品介紹 |
background: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq]. Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. Subunit: Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha). Subcellular Location: Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 4: Cell membrane. Mitochondrion. Tissue Specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). Post-translational modifications: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. Similarity: Contains 1 RGS domain. Database links: Entrez Gene: 5997 Human Entrez Gene: 19735 Mouse Omim: 600861 Human SwissProt: P41220 Human SwissProt: O08849 Mouse Unigene: 78944 Human Unigene: 28262 Mouse Unigene: 1892 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. G蛋白信號轉導調節(jié)子2（RGS2）是動物機體中神經、激素及外界信號刺激轉導的重要信號分子，它作為G蛋白分子開關，在廣泛地協調胞外刺激應答中起著重要的作用。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
