| 產(chǎn)品編號(hào) | bs-1319R-AP |
| 英文名稱 | Rabbit Anti-MAPK4/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的絲裂原活化蛋白激酶4抗體 |
| 別 名 | Mitogen-activated protein kinase 4; Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK; MNK2; ERK-4; ERK3; Erk3 related; ERK4; Extracellular signal regulated kinase 4; MAP kinase 4; MAPK 4; MAPK4; Mitogen activated protein kinase 4; MK04_HUMAN; p63 MAPK; p63MAPK; PRKM4; A330097D03Rik; Erk3; p63Mapk; Prkm4. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAPK4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008] Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). Subunit: Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5. Subcellular Location: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. Tissue Specificity: High expression in heart and brain. Post-translational modifications: Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 5596 Human Entrez Gene: 225724 Mouse Omim: 176949 Human SwissProt: P31152 Human SwissProt: Q6P5G0 Mouse Unigene: 433728 Human Unigene: 254517 Mouse Unigene: 146899 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MAP kinase 4（MAPK4）也是MAPK家族成員，具有絲/蘇氨酸激酶活性。參與細(xì)胞生長、增殖、分化、死亡及細(xì)胞間的功能同步等多種生理過程,能夠被諸如細(xì)胞因子、生長因子、神經(jīng)遞質(zhì)、激素、細(xì)胞應(yīng)急以及細(xì)胞粘附等各種刺激因素激活為信號(hào)傳導(dǎo)途中重要的蛋白激酶，MAPK家族成員之間有很高的同源性。 |
