| 產(chǎn)品編號(hào) | bs-6101R-BF488 |
| 英文名稱 | Rabbit Anti-RUNX1T1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的周期素D相關(guān)蛋白抗體 |
| 別 名 | Acute myelogenous leukemia 1 translocation 1 cyclin D related; Acute myelogenous leukemia 1 translocation 1 protein; AML1T1; CBFA2T1; CDR; Core binding factor runt domain alpha subunit 2 translocated to 1; Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related; Cyclin D related; Cyclin D related protein; Eight twenty one protein; Eigth twenty one protein; ETO; ETO protein; MTG 8; MTG 8b; MTG8. MTG8 protein; MTG8b antibody Myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG 8; Protein MTG8; Runt related transcription factor 1 translocated to 1 (cyclin D related); Runt related transcription factor 1 translocated to 1; Runt related transcription factor 1 translocated to 1 cyclin D related; Zinc finger MYND domain containing protein 2; ZMYND 2; ZMYND2. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RUNX1T1/ETO |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene. Subunit: Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. Subcellular Location: Nucleus. Tissue Specificity: Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. Similarity: Belongs to the CBFA2T family. Contains 1 MYND-type zinc finger. Contains 1 TAFH (NHR1) domain. Database links: Entrez Gene: 862 Human Entrez Gene: 12395 Mouse Omim: 133435 Human SwissProt: Q06455 Human SwissProt: Q61909 Mouse Unigene: 368431 Human Unigene: 470961 Mouse Unigene: 4909 Mouse Unigene: 218117 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
