| 產(chǎn)品編號(hào) | bs-20883R |
| 英文名稱 | Rabbit Anti-MRGPRG antibody |
| 中文名稱 | G蛋白偶聯(lián)受體169抗體 |
| 別 名 | G protein coupled receptor 169; G protein coupled receptor MRGG; G-protein coupled receptor 169; GPR169; Mas related G protein coupled receptor member G; MAS related GPR member G; Mas-related G-protein coupled receptor member G; MRGG; MRGPRG. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MRGPRG: 201-289/289 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
MRGG is a 289 amino acid multi-pass membrane protein that functions as an orphan receptor. A member of the G-protein coupled receptor 1 family and Mas subfamily, MRGG is implicated in pain sensation and modulation by regulating nociceptor function. The gene encoding MRGG maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. SWISS: Q86SM5 Gene ID: 386746 Database links: Entrez Gene: 386746 Human SwissProt: Q86SM5 Human Unigene: 730306 Human |
