| 產(chǎn)品編號(hào) | bs-10736R |
| 英文名稱 | Rabbit Anti-COLEC12 antibody |
| 中文名稱 | 凝集胎盤蛋白1抗體 |
| 別 名 | Collectin placenta protein 1; Collectin placenta 1; Collectin-12; hCL-P1; CL-P1; Nurse cell scavenger receptor; Scavenger receptor with C-type lectin; Scavenger receptor class A member 4; COLEC12; CLP1; NSR2; SCARA4; SRCL. COL12_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 81kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COLEC12: 31-130/742 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Colec12 is a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. Colec12 is a scavenger receptor that displays several functions associated with host defense. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast and mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. Subunit: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide. Subcellular Location: Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface. Tissue Specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. Similarity: Contains 1 C-type lectin domain. Contains 3 collagen-like domains. SWISS: Q5KU26 Gene ID: 81035 Database links: Entrez Gene: 421061 Chicken Entrez Gene: 81035 Human Entrez Gene: 140792 Mouse Omim: 607621 Human SwissProt: Q2LK54 Chicken SwissProt: Q5KU26 Human SwissProt: Q8K4Q8 Mouse Unigene: 33741 Chicken Unigene: 4492 Cow Unigene: 464422 Human Unigene: 218571 Mouse Unigene: 31273 Rat
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