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Rabbit Anti-GPR125  antibody (bs-13516R)
~~~促銷代碼KT202410~~~
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產品編號 bs-13516R
英文名稱 Rabbit Anti-GPR125  antibody
中文名稱 G蛋白偶聯(lián)受體125抗體
別    名 FLJ38547; G protein coupled receptor 125; PGR21; Probable G protein coupled receptor 125 precursor; TEM5 like; TEM5L; GP125_HUMAN; GPCR GPR125.  
研究領域 細胞生物  神經(jīng)生物學  信號轉導  細胞粘附分子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 146kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G protein coupled receptor 125: 101-200/1321 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. Considered a novel orphan adhesion-type G-protein-coupled receptor, GPR125 has five leucine rich repeats (LRR), an immunoglobulin (Ig) domain and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal response to brain injury. It is also suggested that GPR125 may be a marker for spermatogonial stem cells. Four isoforms of GPR125 exists due to alternative splicing events.

Function:
Orphan receptor.

Subunit:
Interacts with DLG1.

Subcellular Location:
Cell membrane; Multi pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 5 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.

SWISS:
Q8IWK6

Gene ID:
166647

Database links:

Entrez Gene: 166647 Human

Entrez Gene: 70693 Mouse

Omim: 612303 Human

SwissProt: Q8IWK6 Human

SwissProt: Q7TT36 Mouse



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