| 產(chǎn)品編號 | bs-12318R |
| 英文名稱 | Rabbit Anti-SCUBE2 antibody |
| 中文名稱 | 內(nèi)皮分泌蛋白SCUBE2抗體 |
| 別 名 | 4932442O19Rik; Cegb1; Cegf1; CEGP1; Cegp1 protein; CUB domain and EGF-like repeat containing 1; FLJ16792; FLJ35234; ICRFP703B1614Q5.1; MGC133057; Protein CEGP1; RGD1563998; SCUB2_HUMAN; Scube2; Signal peptide, CUB and EGF-like domain-containing protein 2; Signal peptide, CUB domain, EGF-like 2. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 干細(xì)胞 血管內(nèi)皮細(xì)胞 內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 107kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human SCUBE2: 881-999/999 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SCUBE2 is a 999 amino acid protein that is ubiquitously expressed in adult tissues and belongs to the evolutionarily conserved SCUBE protein family. Containing a CUB domain and nine EGF-like domains, SCUBE2 manifests as a secreted surface-anchored glycoprotein when overexpressed and is considered a novel component of the HH (Hedgehog) signal. The HH signal plays a pivotal role in induction of ventral neuronal and muscle cell types around the midline during vertebrate development. It is suggested that SCUBE2 expression is important in breast cancer progression and may serve as a useful prognostic marker. SCUBE2 forms homo-oligomers and hetero-oligomers with SCUBE1 and SCUBE3. Expressed as three isoforms produced by alternative splicing events, SCUBE2 is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Subunit: Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity). Subcellular Location: Secreted. Tissue Specificity: Expressed in a broad spectrum of adult tissues. Similarity: Contains 1 CUB domain. Contains 9 EGF-like domains. SWISS: Q9NQ36 Gene ID: 57758 Database links: Entrez Gene: 57758 Human Entrez Gene: 56788 Mouse Omim: 611747 Human SwissProt: Q9NQ36 Human SwissProt: Q9JJS0 Mouse Unigene: 523468 Human Unigene: 40447 Mouse |
