| 產(chǎn)品編號 | bs-12127R |
| 英文名稱 | Rabbit Anti-SCN7A antibody |
| 中文名稱 | 鈉離子通道蛋白7α/Na+ CP type VIIα抗體 |
| 別 名 | Putative voltage gated sodium channel subunit alpha Nax; SCN 6A; SCN 7A; SCN6A; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type 7 subunit alpha; Sodium channel protein type VII subunit alpha; Sodium channel voltage gated type VI alpha polypeptide; Sodium channel voltage gated type VII alpha; Sodium channel voltage gated type VII alpha polypeptide; Voltage dependent sodium channel alpha subunit; SCN7A_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 通道蛋白 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 193kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCN7A: 1561-1582/1682 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming Beta subunit, a noncovalently associated Beta 1 subunit and a disulfide-linked Beta 2 subunit. Na+ CP type VII Alpha (Sodium channel protein type 7 subunit alpha), also known as SCN6A, Sodium channel protein cardiac and skeletal muscle subunit alpha and putative voltage-gated sodium channel subunit alpha Nax, is a 1682 amino acid multi-pass membrane protein that belongs to the sodium channel family. Primarily expressed in uterus and heart, Na+ CP type VII Alpha may function in the regulation of salt intake behavior and central sensing of body-fluid sodium levels. Function: Voltage dependent sodium channels mediate the sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, they form a sodium selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. These ion channel proteins exist as heteromultimeric complexes of a large alpha subunit and 1 or 2 smaller beta subunits. SCN7A (Sodium channel protein type 7 subunit alpha) is an alpha subunit and is expressed in heart and uterus. Subcellular Location: Membrane; Multipass membrane protein. Tissue Specificity: Heart and uterus. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily. SWISS: Q01118 Gene ID: 6332 Database links: Entrez Gene: 6332 Human Entrez Gene: 20272 Mouse Omim: 182392 Human SwissProt: Q01118 Human SwissProt: Q62467 Mouse Unigene: 695947 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SCN7A) Polyclonal Antibody, Unconjugated (bs-12127R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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