| 產(chǎn)品編號 | bs-9477R |
| 英文名稱 | Rabbit Anti-CMYA2/PDE4DIP antibody |
| 中文名稱 | 心肌病相關(guān)蛋白2抗體 |
| 別 名 | Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein. |
| 研究領(lǐng)域 | 心血管 信號轉(zhuǎn)導(dǎo) 細(xì)胞骨架 細(xì)胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 265kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP: 1501-1600/2365 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.
Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events. Function: May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Subunit: Interacts with PDE4D (By similarity). Subcellular Location: Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. DISEASE: Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein. Similarity: Contains 1 NBPF domain. SWISS: Q5VU43 Gene ID: 9659 Database links: Entrez Gene: 9659 Human Entrez Gene: 83679 Mouse Omim: 608117 Human SwissProt: Q5VU43 Human SwissProt: Q80YT7 Mouse Unigene: 584841 Human Unigene: 613082 Human Unigene: 657490 Human Unigene: 728768 Human Unigene: 129840 Mouse Unigene: 48693 Rat |
