| 產(chǎn)品編號 | bs-7856R |
| 英文名稱 | ALOXE3 Rabbit pAb |
| 中文名稱 | 過氧化氫異構(gòu)酶ALOXE3抗體 |
| 別 名 | Arachidonate lipoxygenase 3; e LOX 3; E LOX; e-LOX-3; eLOX3; Epidermal lipoxygenase; Epidermis-type lipoxygenase 3; Lipoxygenase 3; LOXE3_HUMAN. |
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Specific References (2) | bs-7856R has been referenced in 2 publications.
[IF=10.753] Jiankang Wang. et al. PM2.5 caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis. SCI TOTAL ENVIRON. 2023 May;872:162089 WB ; Mouse.
[IF=6.244] Chen Y. et al. Prognostic and Predictive Models for Left- and Right- Colorectal Cancer Patients: A Bioinformatics Analysis Based on Ferroptosis-Related Genes.. Front Oncol. 2022 Feb;12:833834-833834 IHC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 細(xì)胞分化 細(xì)胞類型標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 81 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ALOXE3: 141-240/711 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
Tissue specificity:Predominantly expressed in skin.
Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Tissue Specificity: Predominantly expressed in skin. Similarity: Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain. SWISS: Q9BYJ1 Gene ID: 59344 Database links: Entrez Gene: 59344 Human Entrez Gene: 23801 Mouse Omim: 607206 Human SwissProt: Q9BYJ1 Human SwissProt: Q9WV07 Mouse Unigene: 232770 Human Unigene: 41989 Mouse Unigene: 8716 Rat |
