| 產(chǎn)品編號 | bs-7690R |
| 英文名稱 | Rabbit Anti-P2RX4 antibody |
| 中文名稱 | 三磷酸腺苷門控陽離子通道蛋白抗體 |
| 別 名 | ATP gated cation channel protein; ATP receptor; p2rx4; P2RX4_HUMAN; P2X purinoceptor 4; P2X receptor subunit 4; P2X4; P2X4R; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 4; Purinergic receptor P2X4; Purinoceptor P2X4. |
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Specific References (2) | bs-7690R has been referenced in 2 publications.
[IF=5.714] Zi Xuan Li. et al. Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway. INT IMMUNOPHARMACOL. 2022 Dec;113:109326 IHC, IF, WB ; Mouse, Rat.
[IF=4.432] Guo-qing Xia. et al. The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39. Eur J Pharmacol. 2022 Feb;916:174729 WB,IF ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P2RX4: 238-338/388 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP. Function: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Subunit: Functional P2XRs are organized as homomeric and heteromeric trimers. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the P2X receptor family. SWISS: Q99571 Gene ID: 5025 Database links: Entrez Gene: 5025 Human Entrez Gene: 18438 Mouse Entrez Gene: 100458831 Orangutan Omim: 600846 Human SwissProt: Q99571 Human SwissProt: Q9JJX6 Mouse Unigene: 321709 Human Unigene: 290884 Mouse Unigene: 463383 Mouse Unigene: 7176 Rat |
| 產(chǎn)品圖片 |
Sample:
Large intestine (Mouse) Lysate at 40 ug
Placenta (Mouse) Lysate at 40 ug
Primary: Anti-P2RX4 (bs-7690R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 43 kD
Observed band size: 48 kD
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