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Rabbit Anti-Klrb1c  antibody (bs-4682R)
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產(chǎn)品編號 bs-4682R
英文名稱 Rabbit Anti-Klrb1c  antibody
中文名稱 NKR-P1C(NK1.1)抗體
別    名 Killer cell lectin-like receptor subfamily B member 1C; Killer cell lectin-like receptor subfamily B member 1; CD161 antigen-like family member C; Lymphocyte antigen 55c; Ly-55c; NK1.1; NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40; NKR-P1 40; CD161c; Ly55c; Nkrp1c; KLRBC_MOUSE;   
Specific References  (7)     |     bs-4682R has been referenced in 7 publications.
[IF=17.694] Kim, Hyun-Jin. et al. Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma. NAT COMMUN. 2022 Oct;13(1):1-14  IHC ;  Mouse.  
[IF=7.56] Cheekatla, Satyanarayana Swamy, et al. "NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection." PLoS Pathog 12.10 (2016): e1005972.  IHC-P ;  Mouse.  
[IF=6.107] Leimbacher Aurelia C.. et al. Voluntary Exercise Does Not Always Suppress Lung Cancer Progression. ISCIENCE. 2023 Jan 31  IHC ;  Mouse.  
[IF=3.478] Liu G et al. B-cell leukemia/lymphoma 11 promotes angiogenesis in an experimental corneal neovascularization model. Eye,2018 32(7), 1220–1232.  IF ;  Mouse.  
[IF=2.388] Ina B?hr. et al. Characterization of natural killer cells in colorectal tumor tissue of rats fed a control diet or a high-fat diet. Ann Anat. 2021 Jan;233:151586  IHC ;  Rat.  
[IF=2.28] Liu et al. B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. (2018) Eye.(Lond).  IF(ICC) ;  Mouse.  
[IF=0] Uchida T et al. Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56+ T cells.Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F618-F627.  IHF-P ;  Mouse.  
研究領(lǐng)域 免疫學(xué)  干細胞  細胞類型標志物  自然殺傷細胞  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human)
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 25kDa
檢測分子量 40-48
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CD161c/NK1.1: 101-200/223 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Nov 2021]

Function:
Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.

Subunit:
Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed in natural killer cells.

SWISS:
P27814

Gene ID:
17059

Database links:

Entrez Gene: 17059 Mouse

Entrez Gene: 362443 Rat

SwissProt: P27814 Mouse

SwissProt: Q0ZUP0 Rat



產(chǎn)品圖片
Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Thymus tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Mouse Liver tissue lysates Lane 5: Rat Thymus tissue lysates Lane 6: Rat Liver tissue lysates Primary: Anti-Klrb1 (bs-4682R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kDa Observed band size: 48 kDa
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