| 產(chǎn)品編號(hào) | bs-6202R |
| 英文名稱(chēng) | CIKS/TRAF3IP2 Rabbit pAb |
| 中文名稱(chēng) | 核因子NFκB激活蛋白1抗體 |
| 別 名 | Act 1; ACT1; Activator of cAMP responsive element modulator(CREM) in testis; Adapter protein CIKS; C6ORF4; C6ORF5; C6ORF6; Chromosome 6 Open Reading Frame 4; Chromosome 6 Open Reading Frame 5; Chromosome 6 Open Reading Frame 6; CIKS; CIKS_HUMAN; Connection to IKK and SAPK/JNK; Connection to IKK and SAPK/JNK; Nuclear Factor Kappa B Activator 1; Nuclear factor NF kappa B activator 1; Nuclear factor NF-kappa-B activator 1; TRAF3 interacting protein 2; TRAF3-interacting protein 2; TRAF3IP2. |
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Specific References (2) | bs-6202R has been referenced in 2 publications.
[IF=5.201] Janak L. Pathak. et al. Downregulation of Macrophage-Specific Act-1 Intensifies Periodontitis and Alveolar Bone Loss Possibly via TNF/NF-κB Signaling. Front Cell Dev Biol. 2021; 9: 628139 IHC ; Mouse.
[IF=4.259] Wu Z et al. Co-infection of Mycoplasma gallisepticum and Escherichia coli Triggers Inflammatory Injury Involving the IL-17 Signaling Pathway. Front Microbiol. 2019 Nov 15;10:2615. WB ; Chicken.
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| 研究領(lǐng)域 | 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 63 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRAF3IP2: 501-574/574 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. Subunit: Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6. Tissue Specificity: Widely expressed. DISEASE: Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13) [MIM:614070]. PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Similarity: Contains 1 SEFIR domain. SWISS: O43734 Gene ID: 10758 Database links: Entrez Gene: 10758 Human Entrez Gene: 103213 Mouse Omim: 607043 Human SwissProt: O43734 Human Unigene: 561514 Human Unigene: 436686 Mouse Unigene: 9031 Rat |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CIKS) Polyclonal Antibody, Unconjugated (bs-6202R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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