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RND3 Rabbit pAb (bs-6095R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-6095R
英文名稱 RND3 Rabbit pAb
中文名稱 Rho家族GTP酶3抗體
別    名 ARHE; memB; Rho family GTPase 3; Rho8; RhoE; RND3_HUMAN.  
研究領(lǐng)域 腫瘤  細胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Rat (predicted: Mouse,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RND3: 51-150/244 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The Rho family of proteins mediates cytoskeleton organization and cell motility responses. This family contains twenty different members divided into five groups, the Rho-like, Rac-like, Cdc42-like, Rnd and RhoBTB subfamilies. Rho proteins have GTPase activity and bind GTP in their active form and GDP in their inactive form. In their active form they interact with downstream proteins. However, the Rnd subfamily of proteins containing the Rnd1, Rnd2 and RhoE(Rnd3), binds GTP but not GDP and has no GTPase activity. While Rho proteins are required for stress fibre formation in cultured fibroblasts, epithelial and endothelial cells, overexpression of Rnd3 or Rnd1 in the same cells may cause an opposite effect (i.e. decrease in stress fibre). Thus, the Rnd3 protein may act as an antagonist for the Rho proteins either by directly binding to Rho or to other downstream proteins.

Subunit:
Binds ROCK1 (By similarity). Interacts with UBXD5.

Subcellular Location:
Golgi Apparatus; Golgi apparatus membrane; peripheral membrane protein.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the small GTPase superfamily. Rho family.

SWISS:
P61587

Gene ID:
390

Database links:

Entrez Gene: 390 Human

Entrez Gene: 74194 Mouse

Entrez Gene: 397559 Pig

Entrez Gene: 295588 Rat

Omim: 602924 Human

SwissProt: P61587 Human

SwissProt: P61588 Mouse

SwissProt: O77683 Pig

SwissProt: Q6SA80 Rat

Unigene: 6838 Human

Unigene: 46497 Mouse

Unigene: 25153 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RND3) Polyclonal Antibody, Unconjugated (bs-6095R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat stomach tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RND3) Polyclonal Antibody, Unconjugated (bs-6095R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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