| 產(chǎn)品編號(hào) | bs-5995R |
| 英文名稱 | Rabbit Anti-CAMTA1 antibody |
| 中文名稱 | 鈣調(diào)蛋白結(jié)合轉(zhuǎn)錄激活因子1抗體 |
| 別 名 | Calmodulin-binding transcription activator 1; Calmodulin binding transcription activator 1; CMTA1; KIAA0833; CMTA1_HUMAN. |
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Specific References (1) | bs-5995R has been referenced in 1 publications.
[IF=5.241] Pan, Ruijun. et al. CAMTA1–PPP3CA–NFATc4 multi-protein complex mediates the resistance of colorectal cancer to oxaliplatin. Cell Death Discov. 2022 Mar;8(1):1-13 IHC,WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 183kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CAMTA1: 101-200/1673 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CAMTA1 is a transcription activator which is a putatuove tumor suppressor. It is thought to interact with calmodulin. Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma. Function: Transcriptional activator. May act as a tumor suppressor. Subunit: May interact with calmodulin (Potential). Subcellular Location: Nucleus (Probable). Cytoplasm. Tissue Specificity: Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney. Similarity: Belongs to the CAMTA family. Contains 3 ANK repeats. Contains 1 CG-1 DNA-binding domain. Contains 1 IPT/TIG domain. Contains 3 IQ domains. SWISS: Q9Y6Y1 Gene ID: 23261 Database links: Entrez Gene: 23261 Human Entrez Gene: 100072 Mouse Omim: 611501 Human SwissProt: Q9Y6Y1 Human SwissProt: A2A898 Mouse Unigene: 397705 Human Unigene: 671020 Human Unigene: 318846 Mouse |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CAMTA1) Polyclonal Antibody, Unconjugated (bs-5995R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CAMTA1) Polyclonal Antibody, Unconjugated (bs-5995R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Image was kindly submitted by Dr. Luan Zhou at the University of Massachusetts Medical School. Frozen mouse retina stained with Rabbit Anti-CAMTA1 Polyclonal Antibody (bs-5995R)
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