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phospho-ILK-1 (Ser246) Rabbit pAb (bs-5444R)  
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產(chǎn)品編號 bs-5444R
英文名稱 phospho-ILK-1 (Ser246) Rabbit pAb
中文名稱 磷酸化整合素連接激酶1抗體
別    名 ILK-1(phospho S246); ILK-1(phospho Ser246); p-ILK-1(Ser246); 59 kDa serine/threonine protein kinase; 59 kDa serine/threonine-protein kinase; ILK-2; ILK_HUMAN; Integrin linked Kinase; Integrin-linked protein kinase; DKFZp686F1765; EC 2.7.11.1; ILK 1; ILK 2; ILK; ILK1; ILK2; Integrin linked Kinase 2; Integrin linked protein kinase; p59; p59ILK.  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學  神經(jīng)生物學  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human ILK-1 around the phosphorylation site of Ser246: IF(p-S)HP 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.

Function:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Subunit:
Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3 and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with parvins and probably TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1.

Subcellular Location:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Post-translational modifications:
Autophosphorylated on serine residues.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 5 ANK repeats.
Contains 1 protein kinase domain.

SWISS:
Q13418

Gene ID:
3611

Database links:

Entrez Gene: 3611 Human

Entrez Gene: 16202 Mouse

Entrez Gene: 170922 Rat

Omim: 602366 Human

SwissProt: Q13418 Human

SwissProt: O55222 Mouse

SwissProt: Q99J82 Rat

Unigene: 5158 Human

Unigene: 706355 Human

Unigene: 274846 Mouse

Unigene: 95042 Rat



ILK 是一種新發(fā)現(xiàn)的Ser/Thr蛋白激酶。ILK能夠通過與整合素β1亞單位的結(jié)合介導細胞與胞外基質(zhì)的連接,以依賴于PI3K的方式激活,并通過磷酸化下游底物PKB/AKT,GSK3等胞外信號的一項下游傳遞,對細胞的生長,分化,遷移等進行調(diào)控。由于ILK在胞內(nèi)外信號傳導中起著重要的作用。并且抑制ILK的活性能夠?qū)е录毎芷诘耐图毎绦蛐运劳龅膯?,使其成為腫瘤治療和腫瘤藥物的理想靶位點。
產(chǎn)品圖片
Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-phospho-ILK-1(Ser246) (bs-5444R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD
Sample: Muscle (Mouse) Lysate at 40 ug Primary: Anti-phospho-ILK-1(Ser246) (bs-5444R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-ILK-1(Ser246)) Polyclonal Antibody, Unconjugated (bs-5444R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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