| 產(chǎn)品編號(hào) | bs-0076P |
| 英文名稱 | Aβ42 (35-42) Antibody Blocking Peptide |
| 中文名稱 | β淀粉樣肽1-42(C端)封閉多肽 |
| 別 名 | β-Amyloid 1-42; beta Amyloid(1-42); beta Amyloid 1-42; beta-Amyloid 1-42; Amyloid 1-42; A4; AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid Beta A4 Protein Precursor; Amyloid Beta; Amyloid of Aging and Alzheimer Disease; APP; APPI; B Amyloid; Beta APP; Cerebral Vascular Amyloid Peptide; CTFgamma; CVAP; PN II; PN2; PreA4; Protease nexin II; A beta; A4_HUMAN. |
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Specific References (3) | bs-0076P has been referenced in 3 publications.
[IF=7.632] Dongmiao Qin. et al. Design of a Dual-Wavelength Ratiometric Electrochemiluminescence Immunosensor for Sensitive Detection of Amyloid-β Protein in Human Serum. Acs Sustain Chem Eng. 2021;9(22):7541–7549 Other ;
[IF=6.408] Qin, Dongmiao. et al. Construction of efficient electrochemiluminescence resonance energy transfer sensor based on SnO2/SnS2QDs-Ru@IRMOF-3 composite for sensitive detection of procalcitonin. MICROCHIM ACTA. 2022 Nov;189(11):1-15 Other ; Other.
[IF=3.61] Jiasi Yu. et al. Study on multi-target effects of PIMPC on Aβ/Cu2+-induced Alzheimer's disease model of rats. BRAIN RES. 2023 Mar;1802:148226
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| 性 狀 | Lyophilized |
| 物 種 | human |
| 純化方法 | HPLC |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease. SWISS: P05067 Gene ID: 351 Beta-Amyloid 也稱Beta-A4 蛋白，是Beta-淀粉樣蛋白前體（APP）經(jīng)Beta和Gamma分泌酶分解后的產(chǎn)物。是淀粉樣蛋白的主要成分。此蛋白在大腦中形成不容性的沉積物(老年斑),從而具有特殊的AD,Down's綜合癥和老年癡呆癥的形態(tài)學(xué)特征. Beta-淀粉樣蛋白來(lái)自Beta-淀粉樣蛋白原，在腦組織的細(xì)胞外呈絲狀蛋白樣沉積 是淀粉樣結(jié)節(jié)性神經(jīng)炎病變的主要蛋白成分，在神經(jīng)纖維中也有沉積。 Beta-Amyloid1-42在老年性癡呆Alzheimer病中，大腦皮質(zhì)中特征性地出現(xiàn)Beta-淀粉樣蛋白沉積形成的老年斑。 |
