| 產(chǎn)品編號 | bs-2353R |
| 英文名稱 | Rabbit Anti-CMA1 antibody |
| 中文名稱 | 肥大細(xì)胞類糜蛋白酶1抗體 |
| 別 名 | CMA1_HUMAN; Chymase; EC:3.4.21.39; CYH; CYM; Mast Cell Chymase; Alpha-chymase; Mast cell protease I; |
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Specific References (6) | bs-2353R has been referenced in 6 publications.
[IF=11.33] Moretti, Silvia, et al. "A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis." Nature Communications 8 (2017): 14017. IHC-P ; Mouse.
[IF=3.73] Zheng J, Wei C-C, Hase N, Shi K, Killingsworth CR, et al. (2014) Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog. PLoS ONE 9(4): e94732. IHC-P ; Dog.
[IF=3.73] Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, et al. (2013) Characterization of the Cardiac Renin Angiotensin System in Oophorectomized and Estrogen-Replete mRen2.Lewis Rats. PLoS ONE 8(10):e76992. WB ; Rat.
[IF=3.23] Sansoè, Giovanni, et al. "Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data." PLOS ONE11.9 (2016): e0162644. IHC-P ; Human, Rat.
[IF=2.28] Zhao, Zhuo, et al. "GPR30 Decreases Cardiac Chymase/Angiotensin II by Inhibiting Local Mast Cell Number." Biochemical and Biophysical Research Communications (2015). WB, IHC-P ; Rat.
[IF=1.69] Zeng et al. Resveratrol improves prostate fibrosis during progression of urinary dysfunction in chronic prostatitis by mast cell suppression. (2018) Mol.Med.Rep. 17:918-924 WB ; Rat.
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| 研究領(lǐng)域 | 心血管 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Sheep,GuineaPig) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 25kDa |
| 細(xì)胞定位 | 細(xì)胞漿 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CMA1: 28-42/247 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Subcellular Location: Secreted. Cytoplasmic granule. Note=Mast cell granules. Tissue Specificity: Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. Similarity: Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain. SWISS: P23946 Gene ID: 1215 Database links: Entrez Gene: 1215 Human Entrez Gene: 17228 Mouse SwissProt: P23946 Human SwissProt: P21844 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lung (Mouse) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti- Mast Cell Chymase (bs-2353R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 23 kD
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