| 產(chǎn)品編號 | bs-2996R |
| 英文名稱 | Rabbit Anti-CACNB2 antibody |
| 中文名稱 | L-型電壓依賴型鈣通道β抗體 |
| 別 名 | Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Cacnb2; Cacnlb2; VDCC-L Beta; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium channel beta 2c subunit; calcium channel L-type beta 2 subunit; CACB2_HUMAN. |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 74kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CACNB2: 551-655/655 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013] Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Subunit: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Subcellular Location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Similarity: Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain. SWISS: Q08289 Gene ID: 783 Database links: Entrez Gene: 783 Human Entrez Gene: 12296 Mouse Omim: 600003 Human SwissProt: Q08289 Human SwissProt: Q8CC27 Mouse Unigene: 59093 Human Unigene: 313930 Mouse Unigene: 10739 Rat 電壓依賴性鈣通道(VDCC)是生物體內(nèi)一大類鈣通道蛋白,隨著膜電位的改變而出現(xiàn)通道的開放、關(guān)閉和失活,調(diào)節(jié)細(xì)胞內(nèi)Ca2+濃度,最終產(chǎn)生生物學(xué)效應(yīng).其亞型結(jié)構(gòu)各異,VDCC β亞基具有調(diào)節(jié)其通道活性的作用,VDCC存在的普遍性決定了其作用的廣泛性.在胰腺、心、腦、腎上腺、視網(wǎng)膜及神經(jīng)等組織器官均有不同程度的分布. |
