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FOXF1 Rabbit pAb (bs-2585R)  
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產(chǎn)品編號(hào) bs-2585R
英文名稱(chēng) FOXF1 Rabbit pAb
中文名稱(chēng) 叉頭蛋白F1抗體
別    名 AI450827; FKH L5; FKHL 5; FKHL5; FKHL5; Forkhead(Drosophila) like 5; forkhead(Drosophila)-like 5; forkhead(Drosophila)-like 5; forkhead box F1; forkhead box F1; Forkhead box protein F1; Forkhead drosophila homolog like 5; Forkhead like 5; Forkhead related activator 1; Forkhead related protein FKHL5; Forkhead related transcription factor 1; forkhead-related activator 1; forkhead-related activator 1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FOX F1; FOXF 1; foxf1; FOXF1_HUMAN; FREAC 1; FREAC-1; FREAC1; FREAC1; HFH 8; homolog-like 5; homolog-like 5; MGC105125.  
研究領(lǐng)域 免疫學(xué)  染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Cow,Chicken,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 40 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FOXF1: 285-379/379 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

Function:
Probable transcription activator for a number of lung-specific genes.

Subcellular Location:
Nucleus (Probable).

Tissue Specificity:
Expressed in lung and placenta.

DISEASE:
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]: A rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 fork-head DNA-binding domain.

SWISS:
Q12946

Gene ID:
2294

Database links:

Entrez Gene: 2294 Human

Omim: 601089 Human

SwissProt: Q12946 Human

Unigene: 155591 Human



產(chǎn)品圖片
Sample: Lane 1: Stomach (Mouse) Lysate at 40 ug Lane 2: Lung (Mouse) Lysate at 40 ug Lane 3: Urinary bladder (Mouse) Lysate at 40 ug Lane 4: NIH/3T3 (Mouse) Cell Lysate at 30 ug Primary: Anti-FOXF1 (bs-2585R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 50 kD
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