| 產(chǎn)品編號(hào) | bs-0716R |
| 英文名稱 | Rabbit Anti-CIDEB antibody |
| 中文名稱 | 細(xì)胞死亡激活劑CIDE-B抗體 |
| 別 名 | cell death activator CIDE-B; Cell death activator CIDE B; Cell death inducing DFFA like effector B; CIDEB_HUMAN; cell death-inducing DFFA-like effector B; Cide-b. |
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Specific References (1) | bs-0716R has been referenced in 1 publications.
[IF=2.742] Liu, Yanrong. et al. Cinnamaldehyde affects lipid droplets metabolism after adipogenic differentiation of C2C12 cells. MOL BIOL REP. 2022 Dec;:1-7 WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 染色質(zhì)和核信號(hào) 細(xì)胞凋亡 細(xì)胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 24kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CIDEB: 118-219/219 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow. Function: Activates apoptosis. Subunit: Inhibited by DFFB. Interacts with DFFA and DFFB. Tissue Specificity: Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen. Similarity: Contains 1 CIDE-N domain. SWISS: Q9UHD4 Gene ID: 27141 Database links: Entrez Gene: 27141 Human Entrez Gene: 12684 Mouse Omim: 604441 Human SwissProt: Q546V8 Human SwissProt: Q9UHD4 Human SwissProt: O70303 Mouse Unigene: 642693 Human Unigene: 696081 Human Unigene: 708040 Human Unigene: 466766 Mouse Unigene: 204016 Rat CIDEB是在細(xì)胞凋亡的過程中誘導(dǎo)分泌的一種蛋白，在棕色脂肪組織，肝臟和腎臟中發(fā)現(xiàn)有高水平的DFF45-like effector--DFF45樣效應(yīng)子b蛋白，簡(jiǎn)稱cideb。CIDEB具有調(diào)控脂質(zhì)代謝的作用。 |
| 產(chǎn)品圖片 |
Sample:
Large intestine (Mouse) Lysate at 40 ug
Raw264.7(Mouse) Cell Lysate at 30 ug
Primary: Anti- CIDEB (bs-0716R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24 kD
Observed band size: 27 kD
Sample:
Lane 1: Rat Small intestine tissue lysates
Lane 2: Human HL-60 cell lysates
Primary: Anti-CIDEB (bs-0716R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24 kDa
Observed band size: 27 kDa
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