| 產(chǎn)品編號(hào) | bs-1063R |
| 英文名稱 | Rabbit Anti-ADRB3 antibody |
| 中文名稱 | β3腎上腺素能受體抗體 |
| 別 名 | beta 3 Adrenergic Receptor; beta3-adrenergic receptor; beta3-AR; adrenergic; beta-3- receptor; ADR B3; ADRB 3; ADRB3R; Adrenergic beta 3 receptor; B3AR; Beta 3 adrenoceptor; Beta 3 adrenoreceptor; Beta 3AR; B3AR; BETA3AR; ADRB3_HUMAN. |
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Specific References (7) | bs-1063R has been referenced in 7 publications.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 細(xì)胞膜受體 內(nèi)分泌病 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Pig,Sheep,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADRB3: 310-408/408 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
beta 3 Adrenergic Receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins. beta 3 Adrenergic Receptor expression has been documented in adipose tissues, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of this protein. Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed mainly in adipose tissues. Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. SWISS: P25962 Gene ID: 155 Database links: Entrez Gene: 155 Human Entrez Gene: 11556 Mouse SwissProt: P13945 Human SwissProt: P25962 Mouse Unigene: 2549 Human Unigene: 278475 Mouse Unigene: 10100 Rat Omim: 109691 HumanARβ3是新近發(fā)現(xiàn)的,繼β1和β2之后的第3個(gè)β型腎上腺素受體亞型.分子量：44KDa(404AA) 近年來(lái)研究表明:β3-腎上腺素受體該受體基因突變或基因多態(tài)性與機(jī)體肥胖及心血管疾病相關(guān);心力衰竭時(shí)該受體的含量明顯增加,β3腎上腺素能受體與心血管疾病的相關(guān)研究可能為心血管疾病的預(yù)測(cè)、防治的新方法. |
| 產(chǎn)品圖片 |
Sample:
K562(Human) Cell Lysate at 40 ug
Primary: Anti-beta 3 Adrenergic Receptor (bs-1063R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 44 kD
Observed band size: 54 kD
Tissue/cell: Rat adrenal gland; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-ADRB3 Polyclonal Antibody, Unconjugated(bs-1063R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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