| 產(chǎn)品編號 | bsm-61737R |
| 英文名稱 | SAMHD1/MOP5 Recombinant Rabbit mAb |
| 中文名稱 | 單核細(xì)胞蛋白5重組兔單抗 |
| 別 名 | SAMHD1; AGS5; CHBL2; DCIP; HDDC1; MOP-5; MOP5; SBBI88; Mg11. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,Flow-Cyt=1:20-1:100,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 72 kDa |
| 檢測分子量 | 72 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human SAMHD1: 580-626/626 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks.Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells . SWISS: Q9Y3Z3 Gene ID: 25939 近來經(jīng)科學(xué)家研究發(fā)現(xiàn)，SAMHD1蛋白有抑制骨髓細(xì)胞感染HIV（艾滋病病毒）的機(jī)制，SAMHD1蛋白能感應(yīng)到諸如巨噬細(xì)胞和樹狀細(xì)胞等骨髓細(xì)胞感染到HIV-1病毒（HIV分為1型和2型，1型是目前全球流行的主要毒株，2型目前只在西非流行）和其他相關(guān)的免疫缺陷病毒，并阻止病毒副本在這些細(xì)胞內(nèi)的合成，從而抑制HIV病毒感染。 |
| 產(chǎn)品圖片 |
Western blot analysis of MCF7 cell lysate. Using SAMHD1/MOP5 (bsm-61737R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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