| 產(chǎn)品編號(hào) | bsm-61541R |
| 英文名稱 | Menin Recombinant Rabbit mAb |
| 中文名稱 | Menin抑癌蛋白重組兔單抗 |
| 別 名 | MEA1; Men1; Menin; Multiple Endocrine Adenomatosis 1; Multiple Endocrine Neoplasia 1; SCG2; Suppressor Candidate Gene 2; Wermer syndrome; ZES. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,ICC/IF=1:50-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 68 kDa |
| 檢測(cè)分子量 | 68 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Menin: 550-610/610 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. SWISS: O00255 Gene ID: 4221 menin為腫瘤抑制蛋白，在調(diào)節(jié)細(xì)胞增殖、細(xì)胞凋亡、造血作用、白血病發(fā)生以及染色體相關(guān)蛋白等方面有著多種重要及關(guān)鍵的生物學(xué)調(diào)控功能；Menin目前主要在胰島β細(xì)胞增殖調(diào)控、多發(fā)性內(nèi)分泌瘤（MEN1）以及促進(jìn)妊娠糖尿病的發(fā)生等研究方面。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with Menin monoclonal antibody, unconjugated (bsm-61541R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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