| 產(chǎn)品編號(hào) | bsm-61514R |
| 英文名稱 | APG4B Recombinant Rabbit mAb |
| 中文名稱 | 自噬相關(guān)蛋白4B重組兔單抗 |
| 別 名 | Cysteine protease ATG4B; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44 kDa |
| 檢測分子量 | 44 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human ATG4B: 250-300 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy. SWISS: Q9Y4P1 Gene ID: 23192 細(xì)胞自噬（Autophagy）是一種非凋亡性的程序性細(xì)胞死亡即自噬性程序性細(xì)胞死亡，進(jìn)化過程中高度保守，清除降解細(xì)胞內(nèi)受損傷的細(xì)胞結(jié)構(gòu)、衰老的細(xì)胞器、以及不再需要的生物大分子等，在細(xì)胞的生長、發(fā)育和疾病發(fā)生中起著重要的作用。細(xì)胞自噬是一個(gè)高效調(diào)控過程，特異性激酶和鳥嘌呤核苷酸磷酸酶（GTPases）在調(diào)節(jié)自噬通道活性中起著關(guān)鍵作用. |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with APG4B monoclonal antibody, unconjugated (bsm-61514R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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