| 產(chǎn)品編號 | bsm-61495R |
| 英文名稱 | PCSK9 Recombinant Rabbit mAb |
| 中文名稱 | 神經(jīng)細(xì)胞凋亡調(diào)節(jié)轉(zhuǎn)化蛋白1/前蛋白轉(zhuǎn)化酶枯草溶菌素9重組兔單抗 |
| 別 名 | HCHOLA3; LDLCQ1; NARC1; Neural apoptosis regulated convertase 1; PC9; PCSK9; Proprotein convertase 9. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 19A8 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 74 kDa |
| 檢測分子量 | 62,78 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human PCSK9: 550-600/692 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. SWISS: Q8NBP7 Gene ID: 255738 前蛋白轉(zhuǎn)化酶枯草溶菌素9(PCSK9)是近年來新發(fā)現(xiàn)的一種與調(diào)節(jié)脂質(zhì)代謝密切相關(guān)的基因,編碼前蛋白轉(zhuǎn)化酶NARC-1。Narc-1/pcsk9可通過調(diào)節(jié)細(xì)胞表面的低密度脂蛋白受體(LDLR)水平,參與脂質(zhì)代謝,從而在動脈粥樣硬化性疾病的發(fā)生、發(fā)展中發(fā)揮重要作用。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with PCSK9 monoclonal antibody, unconjugated (bsm-61495R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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