| 產(chǎn)品編號(hào) | bsm-61424R |
| 英文名稱 | Ezrin Recombinant Rabbit mAb |
| 中文名稱 | 埃茲蛋白重組兔單抗 |
| 別 名 | CVIL; Cytovillin; Villin2; p81; EZR; VIL2. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:100-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 69 kDa |
| 檢測(cè)分子量 | 80 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Ezrin: 350-400/586 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. SWISS: P15311 Gene ID: 7430 信號(hào)傳導(dǎo)（Signaling Intermediates） 目前研究發(fā)現(xiàn)Ezrin蛋白與維持細(xì)胞的形狀、極性、生長(zhǎng)運(yùn)動(dòng)以及信號(hào)轉(zhuǎn)導(dǎo)方面發(fā)揮重要作用，該蛋白與腫瘤的侵襲、轉(zhuǎn)移有關(guān)。Erzin是埃茲蛋白（Ezrin）、根蛋白（Radxin）、膜突蛋白（Moesin）（ERM）家族成員，是一種位于細(xì)胞表面受體，黏附分子和肌動(dòng)蛋白細(xì)胞骨架間的連接蛋白。Ezrin活性由N端和C端ERM締合結(jié)構(gòu)域間的分子內(nèi)相互作用所調(diào)節(jié)。ERM家族在上皮細(xì)胞瘤中表達(dá)，它們可能在癌變過程中扮演重要角色。 |
| 產(chǎn)品圖片 |
Western blot analysis of HeLa cell lysate. Using Ezrin (bsm-61424R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
|
