| 產(chǎn)品編號 | bsm-61196R |
| 英文名稱 | Phospho-beta Arrestin 1 (Ser412) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化β-抑制蛋白1重組兔單抗 |
| 別 名 | ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應 | Human |
| 產(chǎn)品應用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測分子量 | 50 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. SWISS: P49407 Gene ID: 408 β抑制因子-1是調(diào)節(jié)CD4+T細胞存活和自身免疫性的關鍵因子，與促進T淋巴細胞存活和自身免疫發(fā)病相關。經(jīng)研究發(fā)現(xiàn)β-arrestin不僅僅能阻斷蛋白合成，也能誘導蛋白合成，參與信號傳導。 對Arrestins家族的研究-探究β-arrestin在G蛋白偶聯(lián)受體信號傳導通路中的地位和作用，是當今生物學中信號傳導研究領域的熱門課題. β抑制因子-1又稱“胰島素受體復合體”，近年來國內(nèi)外科研人員對β-arrestin在II型糖尿病發(fā)生的研究機制方面有了新的突破，認為：β-arre |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
